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EAT BRAINS.

(You may cast it from your graveyard for its escape cost this turn.) If a spell you're casting with escape has an additional cost of discarding cards or sacrificing permanents, you may exile cards discarded or sacrificed this way to pay that part of its escape cost

While that's not the most terrible idea, the likelihood in a Niv-Mizzet deck is that the other spell you're casting is a burn spell that could do the same, and I have to feel that you're going to be better off casting it by itself, rather than putting all your eggs in one basket